Derniers dépôts sur Hal UA

• [halshs-03783060] « Tous sous le même maillot » ? Conditions d’émergence, d’existence et de maintien d’un sujet politique Gilet jaune

  21 sept. 2022 20:24

  I. Moraliser l’économie au travers du vote : une disposition commune à l’engagement en jaune qui n’engage pas nécessairement les mêmes imputations et positionnements en son sein II. Politisation et constitution d’un sujet politique jaune autour de la revalorisation du travail et d’une conscientisation populaire unitaire, fragilisée à l’épreuve des rapports de force internes et externes. Lire le document sur : <a href="https://www.afsp.info/congres/congres-2022/sections-thematiques/st-29/" target="_blank">https://www.afsp.info/congres/congres-2022/sections-thematiques/st-29/</a> Choisir programme puis Session 2 – Jeux d’échelle autour de la subjectivation / Axe 3 : Valeurs, subjectivation et émancipation.

• [hal-03799154] A novel capnogram analysis to guide ventilation during cardiopulmonary resuscitation: clinical and experimental observations

  5 oct. 2022 18:39

  Background Cardiopulmonary resuscitation (CPR) decreases lung volume below the functional residual capacity and can generate intrathoracic airway closure. Conversely, large insufflations can induce thoracic distension and jeopardize circulation. The capnogram (CO2 signal) obtained during continuous chest compressions can reflect intrathoracic airway closure, and we hypothesized here that it can also indicate thoracic distension. Objectives To test whether a specific capnogram may identify thoracic distension during CPR and to assess the impact of thoracic distension on gas exchange and hemodynamics. Methods (1) In out-of-hospital cardiac arrest patients, we identified on capnograms three patterns: intrathoracic airway closure, thoracic distension or regular pattern. An algorithm was designed to identify them automatically. (2) To link CO2 patterns with ventilation, we conducted three experiments: (i) reproducing the CO2 patterns in human cadavers, (ii) assessing the influence of tidal volume and respiratory mechanics on thoracic distension using a mechanical lung model and (iii) exploring the impact of thoracic distension patterns on different circulation parameters during CPR on a pig model. Measurements and main results (1) Clinical data: 202 capnograms were collected. Intrathoracic airway closure was present in 35%, thoracic distension in 22% and regular pattern in 43%. (2) Experiments: (i) Higher insufflated volumes reproduced thoracic distension CO2 patterns in 5 cadavers. (ii) In the mechanical lung model, thoracic distension patterns were associated with higher volumes and longer time constants. (iii) In six pigs during CPR with various tidal volumes, a CO2 pattern of thoracic distension, but not tidal volume per se, was associated with a significant decrease in blood pressure and cerebral perfusion. Conclusions During CPR, capnograms reflecting intrathoracic airway closure, thoracic distension or regular pattern can be identified. In the animal experiment, a thoracic distension pattern on the capnogram is associated with a negative impact of ventilation on blood pressure and cerebral perfusion during CPR, not predicted by tidal volume per se.

• [hal-03799022] Oral Janus kinase inhibitors and venous thromboembolic events in atopic dermatitis: protocols for a case-time control study and a nested case-control study based on the French national health insurance (SNDS) cohort

  5 oct. 2022 17:54

  Introduction Atopic dermatitis (AD) is a highly prevalent, chronic, inflammatory skin disease. Several orally administered Janus kinase inhibitors (JAKis, including baricitinib, upadacitinib and abrocitinib) have received a marketing authorisation for AD. Clinical trials in rheumatoid arthritis (RA) have flagged up a potential risk of JAKi-induced venous thromboembolic events (VTEs). Accordingly, the summary of product characteristics for a JAKi must mention VTEs as potential adverse drug reactions. In contrast to RA, AD per se is not associated with an elevated risk of VTEs. Assessing this potential risk among patients with AD would shed further light on the putative underlying relationship between JAKis and VTEs. Our research question is to investigate whether JAKi administration increases the risk of VTEs in adults with AD. Our primary objective is to assess the risk of VTEs in adults with AD exposed to JAKis compared to AD adults not exposed to JAKis, and our secondary objective is to evaluate whether JAKi initiation acts as a trigger of VTEs in adults with AD within 3 months. Methods and analysis Hence, we have designed (1) a nested case-control study and (2) a case-time control study in a cohort of adults with AD with data from the French national health insurance system (2017-2025). Here, we describe the study protocol, our methodological choices and certain novel aspects, including the combined value of the two assumptions and the use of an exhaustive national health insurance database with potentially greater statistical power for studying rare events in the population of patients with AD at a low risk of VTEs (thus limiting the influence of confounding factors). Ethics and dissemination The protocol has been approved by an independent ethics committee and registered with the French National Data Protection Commission. The study's findings will be published in peer-reviewed scientific journals and presented at international conferences.

• [hal-03799000] Development of bioassays using the zebrafish larva model to screen endocrine disruptors for their involvement in the pathological progression of non-alcoholic fatty liver diseases

  5 oct. 2022 17:47

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• [hal-03798985] Multi-omics integrated analysis reveals significant metabolic disorders from 2D and 3D HepaRG eparg cells after exposure to amiodarone and DEHP

  5 oct. 2022 17:43

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• [hal-03798968] Characterisation of the effects of Ketoconazole and Diethylstilbestrol on the human fetal adrenal

  5 oct. 2022 17:37

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• [hal-03798936] From molecules to phenotype: mechanisms involved in stress, sociability and hypolocomotion after chronic gamma radiation in adult zebrafish

  5 oct. 2022 17:25

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• [hal-03798929] Knowledge gaps: case studies from human fetal ovary and adrenal gland

  5 oct. 2022 17:23

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• [hal-03798435] Metabolomic and lipidomic profiling of zebrafish (danio rerio) embryos exposed to amiodarone and DEHP

  5 oct. 2022 13:31

  Poster Presentations P-20 | Omics approaches in toxicology

• [hal-02899215] Local Perceptions, Vulnerability and Adaptive Responses to Climate Change and Variability in a Winegrowing Region in Uruguay

  15 juil. 2020 03:04

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