Anne-Laure Guihot

Thèmes de recherche

Le laboratoire étudie des dysfonctionnements du système artériel périphérique, ainsi nous nous intéressons à des pathologies impliquant des dysfonctions des artères résistives et en particuliers l’hypertension artérielle et les troubles métaboliques tels que le diabète et l’obésité.

Et plus particulièrement le remodelage Flux-dépendant : influence de l’âge et du genreResp : Daniel Henrion (DR1), Vincent Procaccio (PU-PH1)

Les artères de résistance s'adaptent aux variations de débit survenant lors de la croissance, de la grossesse ou dans les pathologies ischémiques. Nous en étudions les mécanismes afin de trouver de nouvelles voies thérapeutiques.

Publications

Role of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries.

Tarhouni K, Freidja ML, Guihot AL, Vessieres E, Grimaud L, Toutain B, Lenfant F, Arnal JF, Loufrani L, Henrion D.

Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H504-14.

 

Time-related alteration in flow- (shear stress-) mediated remodeling in resistance arteries from spontaneously hypertensive rats.

Dumont O, Kauffenstein G, Guihot AL, Guérineau NC, Abraham P, Loufrani L, Henrion D.

Int J Hypertens. 2014;2014:859793. doi: 10.1155/2014/859793. Epub 2014 May 8.

 

Determinants of flow-mediated outward remodeling in female rodents: respective roles of age, estrogens, and timing.

Tarhouni K, Guihot AL, Vessières E, Toutain B, Procaccio V, Grimaud L, Loufrani L, Lenfant F, Arnal JF, Henrion D.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1281-9. doi: 10.1161/ATVBAHA.114.303404. Epub 2014 Apr 3.

 

AGEs breaking and antioxidant treatment improves endothelium-dependent dilation without effect on flow-mediated remodeling of resistance arteries in old Zucker diabetic rats.

Freidja ML, Vessières E, Toutain B, Guihot AL, Custaud MA, Loufrani L, Fassot C, Henrion D.

Cardiovasc Diabetol. 2014 Mar 3; 13:55. doi: 10.1186/1475-2840-13-55.

 

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90. doi: 10.1073/pnas.1322057111. Epub 2013 Dec 26.

 

COX-2-derived prostanoids and oxidative stress additionally reduce endothelium-mediated relaxation in old type 2 diabetic rats.

Vessières E, Guihot AL, Toutain B, Maquigneau M, Fassot C, Loufrani L, Henrion D.

PLoS One. 2013 Jul 9;8(7):e68217. doi: 10.1371/journal.pone.0068217. Print 2013.

 

Cyclooxygenase-2-derived prostanoids reduce inward arterial remodeling induced by blood flow reduction in old obese Zucker rat mesenteric arteries.

Vessières E, Belin de Chantemèle EJ, Guihot AL, Jardel A, Toutain B, Loufrani L, Henrion D.

Vascul Pharmacol. 2013 May-Jun;58(5-6):356-62. doi: 10.1016/j.vph.2013.03.001. Epub 2013 Mar 21.

 

Key role of estrogens and endothelial estrogen receptor α in blood flow-mediated remodeling of resistance arteries.

Tarhouni K, Guihot AL, Freidja ML, Toutain B, Henrion B, Baufreton C, Pinaud F, Procaccio V, Grimaud L, Ayer A, Loufrani L, Lenfant F, Arnal JF, Henrion D.

Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):605-11. doi: 10.1161/ATVBAHA.112.300334. Epub 2013 Jan 3.

 

Heme oxygenase-1 induction restores high-blood-flow-dependent remodeling and endothelial function in mesenteric arteries of old rats.

Freidja ML, Vessieres E, Clere N, Desquiret V, Guihot AL, Toutain B, Loufrani L, Jardel A, Procaccio V, Faure S, Henrion D.

J Hypertens. 2011 Jan;29(1):102-12. doi: 10.1097/HJH.0b013e32833db36e.

 

In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring.

Duong Van Huyen JP, Vessières E, Perret C, Troise A, Prince S, Guihot AL, Barbry P, Henrion D, Bruneval P, Laurent S, Lelièvre-Pégorier M, Fassot C.

Diabetes. 2010 Oct;59(10):2597-602. doi: 10.2337/db10-0311. Epub 2010 Jul 9.

 

Involvement of angiotensin II in the remodeling induced by a chronic decrease in blood flow in rat mesenteric resistance arteries.

Baron-Menguy C, Toutain B, Cousin M, Dumont O, Guihot AL, Vessières E, Subra JF, Custaud MA, Loufrani L, Henrion D.

Hypertens Res. 2010 Aug;33(8):857-66. doi: 10.1038/hr.2010.83. Epub 2010 Jun 10.

 

Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis.

Clere N, Corre I, Faure S, Guihot AL, Vessières E, Chalopin M, Morel A, Coqueret O, Hein L, Delneste Y, Paris F, Henrion D.

Int J Cancer. 2010 Nov 15;127(10):2279-91. doi: 10.1002/ijc.25234.

 

Cyclooxygenase-2 inhibition restored endothelium-mediated relaxation in old obese zucker rat mesenteric arteries.

Vessières E, Belin de Chantemèle EJ, Toutain B, Guihot AL, Jardel A, Loufrani L, Henrion D.

Front Physiol. 2010 Nov 2;1:145. doi: 10.3389/fphys.2010.00145. eCollection 2010.

 

Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker rat mesenteric arteries.

Belin de Chantemèle EJ, Vessières E, Guihot AL, Toutain B, Loufrani L, Henrion D.

Cardiovasc Res. 2010 Jun 1;86(3):516-25. doi: 10.1093/cvr/cvp411. Epub 2009 Dec 23.

 

Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries.

Retailleau K, Belin de Chantemèle EJ, Chanoine S, Guihot AL, Vessières E, Toutain B, Faure S, Bagi Z, Loufrani L, Henrion D.

Hypertension. 2010 Feb;55(2):339-44. doi: 10.1161/HYPERTENSIONAHA.109.140236. Epub 2009 Dec 21.

 

Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries.

Cousin M, Custaud MA, Baron-Menguy C, Toutain B, Dumont O, Guihot AL, Vessières E, Subra JF, Henrion D, Loufrani L.

Hypertension. 2010 Jan;55(1):109-15. doi: 10.1161/HYPERTENSIONAHA.108.127456. Epub 2009 Nov 30.

 

Reactive oxygen species are necessary for high flow (shear stress)-induced diameter enlargement of rat resistance arteries.

Belin de Chantemèle EJ, Vessières E, Dumont O, Guihot AL, Toutain B, Loufrani L, Henrion D.

Microcirculation. 2009 Jul;16(5):391-402. doi: 10.1080/10739680902816301. Epub 2009 Apr 7.

 

Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow.

Belin de Chantemèle EJ, Vessières E, Guihot AL, Toutain B, Maquignau M, Loufrani L, Henrion D.

Cardiovasc Res. 2009 Mar 1;81(4):788-96. doi: 10.1093/cvr/cvn334. Epub 2008 Dec 2.

 

Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries.

Belin de Chantemèle EJ, Retailleau K, Pinaud F, Vessières E, Bocquet A, Guihot AL, Lemaire B, Domenga V, Baufreton C, Loufrani L, Joutel A, Henrion D.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2216-24. doi: 10.1161/ATVBAHA.108.171751. Epub 2008 Sep 25.

 

Application of saturation dye 2D-DIGE proteomics to characterize proteins modulated by oxidized low density lipoprotein treatment of human macrophages.

Dupont A, Chwastyniak M, Beseme O, Guihot AL, Drobecq H, Amouyel P, Pinet F.

J Proteome Res. 2008 Aug;7(8):3572-82. doi: 10.1021/pr700683s. Epub 2008 Jun 13.

 

Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine.

Dumont O, Pinaud F, Guihot AL, Baufreton C, Loufrani L, Henrion D.

Cardiovasc Res. 2008 Feb 1;77(3):600-8. Epub 2007 Oct 30.

 

Effects of red wine polyphenols on postischemic neovascularization model in rats: low doses are proangiogenic, high doses anti-angiogenic.

Baron-Menguy C, Bocquet A, Guihot AL, Chappard D, Amiot MJ, Andriantsitohaina R, Loufrani L, Henrion D.

FASEB J. 2007 Nov;21(13):3511-21. Epub 2007 Jun 26.

 

Flow-induced remodeling in resistance arteries from obese Zucker rats is associated with endothelial dysfunction.

Bouvet C, Belin de Chantemèle E, Guihot AL, Vessières E, Bocquet A, Dumont O, Jardel A, Loufrani L, Moreau P, Henrion D.

Hypertension. 2007 Jul;50(1):248-54. Epub 2007 May 21.

 

Profiling of membrane proteins from human macrophages: comparison of two approaches.

Slomianny MC, Dupont A, Bouanou F, Beseme O, Guihot AL, Amouyel P, Michalski JC, Pinet F.

Proteomics. 2006 Apr;6(8):2365-75.

 

The proteome and secretome of human arterial smooth muscle cells.

Dupont A, Corseaux D, Dekeyzer O, Drobecq H, Guihot AL, Susen S, Vincentelli A, Amouyel P, Jude B, Pinet F.

Proteomics. 2005 Feb;5(2):585-96.

 

Two-dimensional maps and databases of the human macrophage proteome and secretome.

Dupont A, Tokarski C, Dekeyzer O, Guihot AL, Amouyel P, Rolando C, Pinet F.

Proteomics. 2004 Jun;4(6):1761-78.

 

Morphology, homogeneity and functionality of human monocytes-derived macrophages.

Pinet F, Dupont A, Bencherif N, Guihot AL, Quatannens B, Amouyel P.

Cell Mol Biol (Noisy-le-grand). 2003 Sep;49(6):899-905.

PMID: 14656047

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• Courriel : anne-laure.guihot @ univ-angers.fr (anne-laure.guihot @ univ-angers.fr)