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Linda GrimaudLaboratoire MITOVASC -INSERM U1083 Equipe 2 : CARME Plateau Culture cellulaire IRIS 2 / Laboratoire MITOVASC -INSERM U1083 Equipe 2 : CARME Plateau Culture cellulaire IRIS 2
- Faculté de santé
- Département Médecine
0244688267 - 28 rue Roger Amsler - CS 74521 - 49045 - Angers cedex 01
- Laboratoire MITOVASC -INSERM U1083 Equipe 2 : CARME Plateau Culture cellulaire IRIS 2
- 02 41 73 59 53
- Faculté de santé
- Aide à la Recherche
Laboratoire MITOVASC -INSERM U1083 Equipe 2 : CARME Plateau Culture cellulaire IRIS 2 - 0244688267
- 28 rue Roger Amsler - CS 74521 - 49045 - Angers cedex 01
- The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production. Caillon A, Grenier C, Grimaud L, Vessieres E, Guihot AL, Blanchard S, Lelievre E, Chabbert M, Foucher ED, Jeannin P, Beauvillain C, Abraham P, Loufrani L, Delneste Y, Henrion D. Cardiovasc Res. 2016 Jun 21. pii: cvw172. [Epub ahead of print]
- Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone. Kauffenstein G, Tamareille S, Prunier F, Roy C, Ayer A, Toutain B, Billaud M, Isakson BE, Grimaud L, Loufrani L, Rousseau P, Abraham P, Procaccio V, Monyer H, de Wit C, Boeynaems JM, Robaye B, Kwak BR, Henrion D. Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1598-606. doi: 10.1161/ATVBAHA.116.307739. Epub 2016 Jun 2.
- Resveratrol Improved Flow-Mediated Outward Arterial Remodeling in Ovariectomized Rats with Hypertrophic Effect at High Dose. Petit M, Guihot AL, Grimaud L, Vessieres E, Toutain B, Menet MC, Nivet-Antoine V, Arnal JF, Loufrani L, Procaccio V, Henrion D. PLoS One. 2016 Jan 6;11(1):e0146148. doi: 10.1371/journal.pone.0146148. eCollection 2016.
- Estrogens are needed for the improvement in endothelium-mediated dilation induced by a chronic increase in blood flow in rat mesenteric arteries. Tarhouni K, Guihot AL, Vessieres E, Procaccio V, Grimaud L, Abraham P, Lenfant F, Arnal JF, Favre J, Loufrani L, Henrion D. Vascul Pharmacol. 2016 May;80:35-42. doi: 10.1016/j.vph.2015.10.004. Epub 2015 Oct 22.
- Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease. Camus SM, De Moraes JA, Bonnin P, Abbyad P, Le Jeune S, Lionnet F, Loufrani L, Grimaud L, Lambry JC, Charue D, Kiger L, Renard JM, Larroque C, Le Clésiau H, Tedgui A, Bruneval P, Barja-Fidalgo C, Alexandrou A, Tharaux PL, Boulanger CM, Blanc-Brude OP. Blood. 2015 Jun 11;125(24):3805-14. doi: 10.1182/blood-2014-07-589283. Epub 2015 Mar 31.
- Role of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries. Tarhouni K, Freidja ML, Guihot AL, Vessieres E, Grimaud L, Toutain B, Lenfant F, Arnal JF, Loufrani L, Henrion D. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H504-14.
- Determinants of flow-mediated outward remodeling in female rodents: respective roles of age, estrogens, and timing. Tarhouni K, Guihot AL, Vessières E, Toutain B, Procaccio V, Grimaud L, Loufrani L, Lenfant F, Arnal JF, Henrion D. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1281-9. doi: 10.1161/ATVBAHA.114.303404. Epub 2014 Apr 3.
- Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum. Kauffenstein G, Pizard A, Le Corre Y, Vessières E, Grimaud L, Toutain B, Labat C, Mauras Y, Gorgels TG, Bergen AA, Le Saux O, Lacolley P, Lefthériotis G, Henrion D, Martin L. Arterioscler Thromb Vasc Biol. 2014 May;34(5):1045-56. doi: 10.1161/ATVBAHA.113.302943. Epub 2014 Mar 27. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):e16.
- Key role of estrogens and endothelial estrogen receptor α in blood flow-mediated remodeling of resistance arteries. Tarhouni K, Guihot AL, Freidja ML, Toutain B, Henrion B, Baufreton C, Pinaud F, Procaccio V,Grimaud L, Ayer A, Loufrani L, Lenfant F, Arnal JF, Henrion D. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):605-11. doi: 10.1161/ATVBAHA.112.300334. Epub 2013 Jan 3.
- Selective involvement of serum response factor in pressure-induced myogenic tone in resistance arteries. Retailleau K, Toutain B, Galmiche G, Fassot C, Sharif-Naeini R, Kauffenstein G, Mericskay M, Duprat F, Grimaud L, Merot J, Lardeux A, Pizard A, Baudrie V, Jeunemaitre X, Feil R, Göthert JR, Lacolley P, Henrion D, Li Z, Loufrani L. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):339-46. doi: 10.1161/ATVBAHA.112.300708. Epub 2012 Dec 20.
- Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease. Camus SM, Gausserès B, Bonnin P, Loufrani L, Grimaud L, Charue D, De Moraes JA, Renard JM, Tedgui A, Boulanger CM, Tharaux PL, Blanc-Brude OP. Blood. 2012 Dec 13;120(25):5050-8. doi: 10.1182/blood-2012-02-413138. Epub 2012 Sep 13.
- Ghaboura N, Tamareille S, Ducluzeau PH, Grimaud L, Loufrani L, Croué A, Tourmen Y, Henrion D, Furber A, Prunier F. Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling. Basic Res Cardiol. 2011 Jan;106(1):147-62. Epub 2010 Oct 28
- Venereau E, Diveu C, Grimaud L, Ravon E, Froger J, Preisser L, Danger Y, Maillasson M, Garrigue-Antar L, Jacques Y, Chevalier S, Gascan H. Definition and characterization of an inhibitor for interleukin-31. J Biol Chem. 2010 May 14;285(20):14955-63. Epub 2010 Mar 24
- Le Saux S, Rousseau F, Barbier F, Ravon E, Grimaud L, Danger Y, Froger J, Chevalier S, Gascan H. Molecular dissection of human interleukin-31-mediated signal transduction through site-directed mutagenesis. J Biol Chem. 2010 Jan 29;285(5):3470-7. Epub 2009 Nov 17.
- Rousseau F, Chevalier S, Guillet C, Ravon E, Diveu C, Frojer J, Barbier F, Grimaud L, Gascan H. Ciliary neutrophic factor, cardiotrophin-like cytokine and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain. J Biol Chem. 2008 Oct 31; 283(44):30341-50.
- Duluc D., Delneste Y., Tan F., Moles MP., Grimaud L., Lenoir J., Preisser L., Anegon I., Catala L., Ifrah N., Descamps P., Gamelin E., Gascan H., Hebbar M., Jeannin P. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated-macrophage-like cells. Blood. 2007 Dec 15; 110(13):4319-30.
- Diveu C, Venereau E, Froger J, Ravon E, Grimaud L, Rousseau F, Chevalier S, Gascan H. Molecular and functional characterization of a soluble form of oncostatin M / interleukin-31 shared receptor. J Biol Chem. 2006 Dec 1;281(48):36673-82.
- Diveu C, Lak-Hal AH, Froger J, Ravon E, Grimaud L, Barbier F, Hermann J, Gascan H, Chevalier S. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur. Cytokine Netw. 2004 Oct-Dec;15(4):291-302.
- Marot-Leblond A, Grimaud L, David S, Sullivan DJ, Coleman DC, Ponton J, Robert R. Evaluation of a rapid immunochromatographic assay for identification of Candida albicans and Candida dubliniensis. J Clin Microbiol. 2004 Nov;42(11):4956-60.
- Marot-Leblond A., Grimaud L., Nail S., Bouterige S., Apaire-Marchais V., Sullivan D.J. and Robert R. New monoclonal antibody specific for Candida albicans germ tube. J. Clin. Microbiol. 2000, 38: 61-67.
- Michel F., Grimaud L., Tuosto L. and Acuto O. Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells. J. Biol. Chem. 1998, 273: 31932-31938.
- Courriel : linda.grimaud @ univ-angers.fr
Afficher UFR de Médecine sur une carte plus grande
Afficher UFR de Médecine sur une carte plus grande
Discipline
Les travaux de l’unité portent sur les différents aspects de la fonction vasculaire chez le sujet sain ainsi que sur les dysfonctions liées aux principales pathologies cardiovasculaires. La signalisation impliquée dans la réponse microvasculaire à la pression et au débit est étudiée in vivo et in vitro dans des modèles murins de pathologies humaines (hypertension, diabète, obésité). J’occupe un poste lié à la fois au fonctionnement général de l’unité ainsi qu’aux projets de recherche.
Thèmes de recherche
Mécanotransduction Vasculaire; rôle des systèmes neuro-humoraux locaux.
Remodelage Flux-dépendant : influence de l’âge et du genre.
Rôle des protéines du Cytosquelette dans la Mécanotransduction Microvasculaire.
Publications
