Aller au contenuAller au menuAller à la rechercheAller à la page d'actualités

CRT - Université Angers

Cardioprotection, remodelage et trombose | CRT

  • Partager la page sur les réseaux sociaux
  • Envoyer cette page par mail

    Envoyer par mail


    Séparés par des virgules
  • Imprimer cette page

CRT | UPRES EA 3860

Présentation

Pôle

Equipe d'Accueil du pôle de recherche Santé

Responsable(s)

fabrice.prunier @ univ-angers.fr

Nom des équipes

Thème 1 : Imagerie de la cardioprotection et de remodelage cardiaque

Thème 2 : Protection myocardique à la phase aigüe de l’infarctus du myocarde

Thème 3 : Etude des déterminants thrombotiques

 

Membres du laboratoire

Personnel statutaire

Titulaire d'une HDR : Christophe Baufreton (PU-PH), Alain Furber (PU-PH), Pierre Pottier (MCU-PH), Fabrice Prunier (PU-PH) ; Pierre-Marie Roy (PU-PH), Serge Willoteaux (PU-PH)

Praticien hospitalier : Wissam Abi-Khalil, Thomas Benard, Jean-Patrice Binuani, Stéphane Delèpine, Jean-Marc Dupuis, Anthony Foucault, Jacques Laporte, Christian Pelle, Phillipe Pézard, Frédéric Rouleau, Aude Tassin

Personnel contractuel

Ingénieur de recherche : Sophie Tamareille

Infirmière de recherche clinique : Céline Mitonneau

Attaché de recherche clinique : Charles Cornet, Jérémy Rautureau

Doctorants

Oussama Bakhta, Loïc Bière, Laura Cellier

Master 2

Vianney Behaghel, Rima Kamel

Complément

Prix et distinctions

2013: P. Hibert.  Prix de la meilleure communication affichée - "Printemps de la Cardiologie".P. Hibert, D. Mirebeau-Prunier, O. Beseme, M. Chwastyniak, S. Tamareille, D. Lamon, A. Furber, F. Pinet, F. Prunier. Apolipoprotein A-1 is a potential mediator of remote ischemic preconditioning. Archives of Cardiovascular Diseases (2013), Supp. ISSN 1878-6480, Vol. 5, p.19, 104.

2012: F. Prunier: Lauréat de la dotation de recherche de la Fondation Coeur et Recherche (étude EURECA, Effecteur circulant impliqué dans le mécanisme du conditionnement myocardique à distance).

2010 : N. Ghaboura. Prix de la compétition jeunes chercheurs des Journées Européennes de la Société Française de Cardiologie. Ghaboura N., Tamareille S., Ducluzeau P.H., Croué A., Tourmen Y., Henrion D., Furber A., Prunier F. Diabetes Mellitus Abrogates Erythropoietin-Induced Cardioprotection against Ischemic-Reperfusion Injury by Alteration of the RISK/GSK-3β signaling. Archives of Cardiovascular Diseases, Supp ISSN 1878-6480, Vol. 2, Abstract 249.

2010 : N. Ghaboura. Prix de la meilleure communication affichée -"Printemps de la Cardiologie". Ghaboura N., Tamareille S., Ducluzeau P.H., Croué A., Tourmen Y., Henrion D., Furber A., Prunier F. Diabetes Mellitus Abrogates Erythropoietin-Induced Cardioprotection against Ischemic-Reperfusion Injury by Alteration of the RISK/GSK-3β signaling. Archives of Cardiovascular Diseases; Vol.2-Special issue N°1, ISSN 1878-6480, p.28, 0014.

2010 : F. Prunier : Lauréat de la dotation de recherche mixte SFC/FFC (étude RIPOST-MI, Remote Ischemic POSTconditioning in Myocardial Infarction)

2009 : N. Ghaboura : Prix de la compétition jeunes chercheurs des Journées Européennes de la Société Française de Cardiologie. Ghaboura N., Tamareille S., Khachman D., Treguer F., Furber A., Prunier F. Erythropoietin protects the heart against ischemic-reperfusion injury: Comparison with ischemic postconditioning-induced cardioprotection. Archives of Cardiovascular Diseases, 102 A106 A79.

2008 : P.M. Roy. Prix de la meilleure communication : U d'Or. Intérêt d’une aide à la décision sur ordinateurs de poches pour améliorer les pratiques lors des suspicions d’embolie pulmonaire aux Urgences : Etude SPEED. URGENCES 2008 – Société Française de Médecine d'Urgence. JEUR 2008; 21: A127

2006 : F. Prunier : Lauréat de la dotation de recherche mixte SFC/FFC (étude EPOMI, ErythroPOietin in Myocardial Infarction)

 

Thèmes de recherche

Thèmes de recherche / expertise

- Imagerie de la cardioprotection et de remodelage cardiaque

- Protection myocardique à la phase aigüe de l’infarctus du myocarde

- Etude des déterminants thrombotiques

Publications

Publications principales depuis 2008:

2015:

Cellier L, Tamareille S, Kalakech H, Guillou S, Lenaers G, Prunier F, Mirebeau-Prunier D. Remote Ischemic Conditioning Influences Mitochondrial Dynamics. Shock. 2015 Oct 28. [Epub ahead of print]

Le Page S, Prunier F. Remote ischemic conditioning: Current clinical perspectives. J Cardiol. 2015 66(2):91-6. Review.

Le Page S, Bejan-Angoulvant T, Angoulvant D, Prunier F. Remote ischemic conditioning and cardioprotection: a systematic review and meta-analysis of randomized clinical trials. Basic Res Cardiol. 2015 Mar;110(2):11.

Bière L, Launay M, Pinaud F, Hamel JF, Eltchaninoff H, Iung B, Laskar M, Leguerrier A, Gilard M, Furber A. Influence of Sex on Mortality and Perioperative Outcomes in Patients Undergoing TAVR: Insights From the FRANCE 2 Registry. J Am Coll Cardiol. 2015;65(7):755-7.

Pickard JM, Bøtker HE, Crimi G, Davidson B, Davidson SM, Dutka D, Ferdinandy P, Ganske R, Garcia-Dorado D, Giricz Z, Gourine AV, Heusch G, Kharbanda R, Kleinbongard P, MacAllister R, McIntyre C, Meybohm P, Prunier F, Redington A, Robertson NJ, Suleiman MS, Vanezis A, Walsh S, Yellon DM, Hausenloy DJ. Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop. Basic Res Cardiol. 2015;110(1):453.

Touboul C, Angoulvant D, Mewton N, Ivanes F, Muntean D, Prunier F, Ovize M, Bejan-Angoulvant T. Ischaemic postconditioning reduces infarct size: systematic review and meta-analysis of randomized controlled trials. Arch Cardiovasc Dis. 2015 Jan;108(1):39-49. doi: 10.1016/j.acvd.2014.08.004. Epub 2014 Nov 13. PubMed PMID: 25453717.

2014:

Azau A, Markowicz P, Corbeau JJ, Cottineau C, Moreau X, Baufreton C, Beydon L. Increasing mean arterial pressure during cardiac surgery does not reduce the rate of postoperative acute kidney injury. Perfusion. 2014 Nov;29(6):496-504. doi: 10.1177/0267659114527331. Epub 2014 Mar 11.

Koning NJ, Simon LE, Asfar P, Baufreton C, Boer C. Systemic microvascular shunting through hyperdynamic capillaries after acute physiological disturbances following cardiopulmonary bypass. Am J Physiol Heart Circ Physiol. 2014 Oct 1;307(7):H967-75. doi: 10.1152/ajpheart.00397.2014. Epub 2014 Jul 25.

Plumereau F, Pinaud F, Roch A, Baufreton C. Do patients with haematological malignancy who need cardiopulmonary bypass have a short-term higher mortality or a higher chance of disease progression? Interact Cardiovasc Thorac Surg. 2014 Sep;19(3):474-8. doi: 10.1093/icvts/ivu190. Epub 2014 Jun 11.

Aissaoui N, Puymirat E, Simon T, Bonnefoy-Cudraz E, Angoulvant D, Schiele F, Benamer H, Quandalle P, Prunier F, Durand E, Berard L, Blanchard D, Danchin N. Long-term outcome in early survivors of cardiogenic shock at the acute stage of myocardial infarction: a landmark analysis from the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) Registry. Crit Care. 2014 Sep 19;18(5):516. doi: 10.1186/s13054-014-0516-y.

Fokkema ML, van der Meer P, Rao SV, Belonje AM, Ferrario M, Hillege HL, Katz SD, Lipšic E, Ludman AJ, Ott I, Prunier F, Choi DJ, Toba K, van Veldhuisen DJ, Voors AA. Safety and clinical outcome of erythropoiesis-stimulating agents in patients with ST-elevation myocardial infarction: a meta-analysis of individual patient data. Am Heart J. 2014 Sep;168(3):354-362.e2. doi: 10.1016/j.ahj.2014.04.020. Epub 2014 Jun 9. Review.

Pailhoriès H, Lemarié C, Quinqueneau C, Eveillard M, Baufreton C, Rouleau F, Mahaza C, Joly-Guillou ML, Kempf M. First report of endocarditis caused by a Pseudoclavibacter species. J Clin Microbiol. 2014 Sep;52(9):3465-7. doi: 10.1128/JCM.01388-14. Epub 2014 Jul 2.

Roubille F, Mewton N, Elbaz M, Roth O, Prunier F, Cung TT, Piot C, Roncalli J, Rioufol G, Bonnefoy-Cudraz E, Wiedemann JY, Furber A, Jacquemin L, Willoteaux S, Abi-Khallil W, Sanchez I, Finet G, Sibellas F, Ranc S, Boussaha I, Croisille P, Ovize M. No post-conditioning in the human heart with thrombolysis in myocardial infarction flow 2-3 on admission. Eur Heart J. 2014 Jul 1;35(25):1675-82. doi: 10.1093/eurheartj/ehu054. Epub 2014 Feb 28.

Teligui L, Dalmayrac E, Mabilleau G, Macchi L, Godon A, Corbeau JJ, Denommé AS, Bouquet E, Boer C, Baufreton C. An ex vivo evaluation of blood coagulation and thromboresistance of two extracorporeal circuit coatings with reduced and full heparin dose. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):763-9. doi: 10.1093/icvts/ivu011. Epub 2014 Mar 14.

Koning NJ, Vonk AB, Meesters MI, Oomens T, Verkaik M, Jansen EK, Baufreton C, Boer C. Microcirculatory perfusion is preserved during off-pump but not on-pump cardiac surgery. J Cardiothorac Vasc Anesth. 2014 Apr;28(2):336-41. doi: 10.1053/j.jvca.2013.05.026. Epub 2013 Oct 23.

Urdulashvili M, Bière L, Baufreton C, Nedelcu C, Bouvier A, Abi-Khalil W, Thouveny F, Aubé C, Willoteaux S. Aneurysms of the sinus of Valsalva revealed by an acute coronary syndrome. Diagn Interv Imaging. 2014 Apr;95(4):447-9. doi: 10.1016/j.diii.2013.12.005. Epub 2014 Feb 20.

Righini M, Van Es J, Den Exter PL, Roy PM, Verschuren F, Ghuysen A, Rutschmann OT, Sanchez O, Jaffrelot M, Trinh-Duc A, Le Gall C, Moustafa F, Principe A, Van Houten AA, Ten Wolde M, Douma RA, Hazelaar G, Erkens PM, Van Kralingen KW, Grootenboers MJ, Durian MF, Cheung YW, Meyer G, Bounameaux H, Huisman MV, Kamphuisen PW, Le Gal G. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA. 2014 Mar 19;311(11):1117-24. doi: 10.1001/jama.2014.2135. Erratum in: JAMA. 2014 Apr 23-30;311(16):1694.

Bière L, Donal E, Terrien G, Kervio G, Willoteaux S, Furber A, Prunier F. Longitudinal strain is a marker of microvascular obstruction and infarct size in patients with acute ST-segment elevation myocardial infarction. PLoS One. 2014 Jan 28;9(1):e86959. doi: 10.1371/journal.pone.0086959. eCollection 2014.

Grall S, Biere L, Clerfond G, Mateus V, Prunier F, Furber A. ECG characteristics according to the presence of late gadolinium enhancement on cardiac MRI in hypertrophic cardiomyopathy. Open Heart. 2014 Aug 5;1(1):e000101. doi: 10.1136/openhrt-2014-000101. eCollection 2014. PubMed PMID: 25332813; PubMed Central PMCID: PMC4189227.

Kalakech H, Hibert P, Prunier-Mirebeau D, Tamareille S, Letournel F, Macchi L, Pinet F, Furber A, Prunier F. RISK and SAFE signaling pathway involvement in apolipoprotein A-I-induced cardioprotection. PLoS One. 2014;9:e107950.

Bière L, Donal E, Terrien G, Furber A, Martin L, Prunier F. Left ventricular function in a large cohort of pseudoxanthoma elasticum patients. PLoS One. 2014 Mar 20;9(3):e90364.

Hibert P, Prunier-Mirebeau D, Beseme O, Chwastyniak M, Tamareille S, Pinet F, Prunier F. Modifications in rat plasma proteome after remote ischemic preconditioning (RIPC) stimulus: identification by a SELDI-TOF-MS approach. PLoS One. 2014;9:e85669.

Prunier F, Angoulvant D, Saint Etienne C, Vermes E, Gilard M, Piot C, Roubille F, Elbaz M, Ovize M, Bière L, Jeanneteau J, Delépine S, Benard T, Abi-Khalil W, Furber A. The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction. Basic Res Cardiol. 2014;109(2):400. doi: 10.1007/s00395-013-0400-y.

Biere L, Pinaud F, Delépine S, Grall S, Viot N, Mateus V, Rouleau F, Corbeau JJ, Prunier F, De Brux JL, Willoteaux S, Furber A. CMR assessment after a transapical-transcatheter aortic valve implantation. Eur J Radiol. 2014 Feb;83(2):303-8.

Macchi L, Moussa WB, Guillou S, Tamareille S, Lamon D, Prunier D, Prunier F. The synthetic pentasaccharide fondaparinux attenuates myocardial ischemia-reperfusion injury in rats via STAT-3. Shock. 2014 Feb;41(2):166-71.

 

2013:

Kalakech H, Tamareille S, Pons S, Godin-Ribuot D, Carmeliet P, Furber A, Martin V, Berdeaux A, Ghaleh B, Prunier F. Role of hypoxia inducible factor-1α in remote limb ischemic preconditioning. J Mol Cell Cardiol. 2013;65:98-104. doi: 10.1016/j.yjmcc.2013.10.001.

Hibert P, Prunier-Mirebeau D, Beseme O, Chwastyniak M, Tamareille S, Lamon D, Furber A, Pinet F, Prunier F. Apolipoprotein a-I is a potential mediator of remote ischemic preconditioning. PLoS One. 2013;8:e77211. doi: 10.1371/journal.pone.0077211.

Roubille F, Prunier F, Barrère-Lemaire S, Leclercq F, Piot C, Kritikou EA, Rhéaume E, Busseuil D, Tardif JC. What is the role of erythropoietin in acute myocardial infarct? Bridging the gap between experimental models and clinical trials. Cardiovasc Drugs Ther. 2013;27:315-31.

Prunier F, Terrien G, Le Corre Y, Apana AL, Bière L, Kauffenstein G, Furber A, Bergen AA, Gorgels TG, Le Saux O, Leftheriotis G, Martin L. Pseudoxanthoma elasticum: cardiac findings in patients and Abcc6-deficient mouse model. PLoS One. 2013;8:e68700. doi: 10.1371/journal.pone.0068700.

Grall S, Prunier-Mirebeau D, Tamareille S, Mateus V, Lamon D, Furber A, Prunier F. Endoplasmic reticulum stress pathway involvement in local and remote myocardial ischemic conditioning. Shock. 2013;39:433-9. doi: 10.1097/SHK.0b013e31828e4f80.

Fouquet O, Baufreton C, Tassin A, Pinaud F, Binuani JP, Prunier F, Rouleau F, Willoteaux S, de Brux JL, Furber A. Influence des valves stentées et non stentées sur le remodelage ventriculaire Évaluation par IRM à 6 mois et survie à long terme. Chirurgie Thoracique et Cardio-vasculaire. 2013; 17(4): 215-221

Biere L, Donal E, Terrien G, Kervio G, Willoteaux S, Furber A, Prunier F. Longitudinal strain is a marker of microvascular obstruction and infarct size in patients with acute ST-segment elevation myocardial infarction. PLoS One. 2013 (in press)

Helft G, Le Feuvre C, Georges JL, Carrie D, Leclercq F, Eltchaninoff H, Furber A, Prunier F, Sebagh L, Cattan S, Cayla G, Vicaut E, Metzger JP. Efficacy and safety of 12 versus 48 months of dual antiplatelet therapy after implantation of a drug-eluting stent: the OPTImal DUAL antiplatelet therapy (OPTIDUAL) trial: study protocol for a randomized controlled trial. Trials. 2013;14:56.

Lefthériotis G, Omarjee L, Le Saux O, Henrion D, Abraham P, Prunier F, Willoteaux S, Martin L. The vascular phenotype in Pseudoxanthoma elasticum and related disorders: contribution of a genetic disease to the understanding of vascular calcification. Front Genet. 2013;4:4.

Gueret P, Deux JF, Bonello L, Sarran A, Tron C, Christiaens L, Dacher JN, Bertrand D, Leborgne L, Renard C, Caussin C, Cluzel P, Helft G, Crochet D, Vernhet-Kovacsik H, Chabbert V, Ferrari E, Gilard M, Willoteaux S, Furber A, Barone-Rochette G, Jankowski A, Douek P, Mousseaux E, Sirol M, Niarra R, Chatellier G, Laissy JP. Diagnostic performance of computed tomography coronary angiography (from the Prospective National Multicenter Multivendor EVASCAN Study). Am J Cardiol. 2013;111(4):471-8.

Tarhouni K, Guihot AL, Freidja ML, Toutain B, Henrion B, Baufreton C, Pinaud F, Procaccio V, Grimaud L, Ayer A, Loufrani L, Lenfant F, Arnal JF, Henrion D. Key role of estrogens and endothelial estrogen receptor α in blood flow-mediated remodeling of resistance arteries. Arterioscler Thromb Vasc Biol. 2013;33(3):605-11.

Penaloza A, Verschuren F, Meyer G, Quentin-Georget S, Soulie C, Thys F, Roy PM. Comparison of the unstructured clinician gestalt, the wells score, and the revised Geneva score to estimate pretest probability for suspected pulmonary embolism. Ann Emerg Med. 2013 Aug;62(2):117-124.e2. doi: 10.1016/j.annemergmed.2012.11.002.

Sadoul N, Defaye P, Mouton E, Bizeau O, Dupuis JM, Blangy H, Delarche N, Blanc JJ, Lazarus A; LEADER registry investigators. Defibrillation testing in everyday medical practice during implantable cardioverter defibrillator implantation inFrance: Analysis from the LEADER registry. Arch Cardiovasc Dis. 2013 Nov;106(11):562-9.

Sanchez O, Trinquart L, Planquette B, Couturaud F, Verschuren F, Caille V, Meneveau N, Pacouret G, Roy PM, Righini M, Perrier A, Bertoletti L, Parent F, Lorut C, Meyer G. Echocardiography and pulmonary embolism severity index have independent prognostic roles in pulmonary embolism. Eur Respir J. 2013 Sep;42(3):681-8.

Mignon I, Grand F, Boyer F, Hunault-Berger M, Hamel JF, Macchi L. Thrombin generation and procoagulant phospholipids in patients with essential thrombocythemia and reactive thrombocytosis. Am J Hematol. 2013 Dec;88(12):1007-11.

Pénisson-Besnier I, Allamand V, Beurrier P, Martin L, Schalkwijk J, van Vlijmen-Willems I, Gartioux C, Malfait F, Syx D, Macchi L, Marcorelles P, Arbeille B, Croué A, De Paepe A, Dubas F. Compound heterozygous mutations of the TNXB gene cause primary myopathy. Neuromuscul Disord. 2013 Aug;23(8):664-9.

Pinaud F, Daligault M, Enon B, de Brux JL. Endovascular treatment of inoperable acute type A dissection via the transapical approach. Eur Heart J. 2013 Nov;34(41):3236.

Koning NJ, Vonk AB, Meesters MI, Oomens T, Verkaik M, Jansen EK, Baufreton C, Boer C. Microcirculatory Perfusion Is Preserved During Off-Pump but Not On-Pump Cardiac Surgery. J Cardiothorac Vasc Anesth. 2013 Oct 22.

Samama CM, Lecoules N, Kierzek G, Claessens YE, Riou B, Rosencher N, Mismetti P, Sautet A, Barrellier MT, Apartsin K, Jonas M, Caeiro JR, van der Veen AH, Roy PM; FONDACAST Study Group. Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid immobilization for isolated non-surgical below-knee injury. J Thromb Haemost. 2013 Oct;11(10):1833-43.

Bertoletti L, Le Gal G, Aujesky D, Sanchez O, Roy PM, Verschuren F, Bounameaux H, Perrier A, Righini M. Prognostic value of theGenevaprediction rule in patients with pulmonary embolism. Thromb Res. 2013 Jul;132(1):32-6.

Verschuren F, Bonnet M, Benoit MO, Gruson D, Zech F, Couturaud F, Meneveau N, Roy PM, Righini M, Meyer G, Sanchez O. The prognostic value of pro-B-Type natriuretic peptide in acute pulmonary embolism. Thromb Res. 2013 Jun;131(6):e235-9.

Baufreton C, Brochet A, Darrieutort H, Chrétien JM, Parot Schinkel E, Tanguy M, Dalmayrac E, Lehot JJ. [National survey on short-term circulatory and/or respiratory support in 2009]. Ann Fr Anesth Reanim. 2013 Apr;32(4):220-4. doi: 10.1016/j.annfar.2013.01.017. Epub 2013 Mar 6. French.

Chauveau P, Mazet-Guillaume B, Baron C, Roy PM, Tanguy M, Fanello S. [Impact of the referral letter on triage decisions in adult patients admitted to the emergency department]. Sante Publique. 2013 Jul-Aug;25(4):441-51. French.

 

2012:

Jeanneteau J, Hibert P, Martinez MC, Tual-Chalot S, Tamareille S, Furber A, Andriantsitohaina R, Prunier F. Microparticle release in remote ischemic conditioning mechanism. Am J Physiol Heart Circ Physiol. 2012;303(7):H871-7

Prunier F, Bière L, Gilard M, Boschat J, Mouquet F, Bauchart JJ, Charbonnier B, Genée O, Guérin P, Warin-Fresse K, Durand E, Lafont A, Christiaens L, Abi-Khalil W, Delépine S, Benard T, Furber A. Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: results of the erythropoietin in myocardial infarction trial. Am Heart J. 2012 Feb;163(2):200-7

Penaloza A, Kline J, Verschuren F, Courtney DM, Zech F, Derrien B, Vielle B, Armand-Perroux A, Thys F, Roy PM. European and American suspected and confirmed pulmonary embolism populations: comparison and analysis. J Thromb Haemost. 2012 Mar;10(3):375-381.

Gex G, Gerstel E, Righini M, LE Gal G, Aujesky D, Roy PM, Sanchez O,Verschuren F, Rutschmann OT, Perneger T, Perrier A. Is atrial fibrillation associated with pulmonary embolism? J Thromb Haemost. 2012 Mar;10(3):347-351.

Gilard M, Eltchaninoff H, Iung B, Donzeau-Gouge P, Chevreul K, Fajadet J, Leprince P, Leguerrier A, Lievre M, Prat A, Teiger E, Lefevre T, Himbert D, Tchetche D, Carrié D, Albat B, Cribier A, Rioufol G, Sudre A, Blanchard D, Collet F, Dos Santos P, Meneveau N, Tirouvanziam A, Caussin C, Guyon P, Boschat J, Le Breton H, Collart F, Houel R, Delpine S, Souteyrand G, Favereau X, Ohlmann P, Doisy V, Grollier G, Gommeaux A, Claudel JP, Bourlon F, Bertrand B, Van Belle E, Laskar M; FRANCE 2 Investigators. Registry of transcatheter aortic-valve implantation in high-risk patients. N Engl J Med. 2012;366:1705-15.

Caroff J, Bière L, Trebuchet G, Nedelcu C, Sibileau E, Beregi JP, Aubé C, Furber A, Willoteaux S. Applications of phase-contrast velocimetry sequences in cardiovascular imaging. Diagn Interv Imaging. 2012;93:159-70.

Bouvier A, Sentilhes L, Thouveny F, Bouet PE, Gillard P, Willoteaux S, Aubé C. Planned caesarean in the interventional radiology cath lab to enable immediate uterine artery embolization for the conservative treatment of placenta accreta. Clin Radiol. 2012;67:1089-94.

Le Corre Y, Le Saux O, Froeliger F, Libouban H, Kauffenstein G, Willoteaux S, Leftheriotis G, Martin L. Quantification of the calcification phenotype of Abcc6-deficient mice with microcomputed tomography. Am J Pathol. 2012;180:2208-13.

Moubarak E, Bouvier A, Boursier J, Lebigot J, Ridereau-Zins C, Thouveny F, Willoteaux S, Aubé C. Portosystemic collateral vessels in liver cirrhosis: a three-dimensional MDCT pictorial review. Abdom Imaging. 2012;37:746-66.

Mabo P, Cebron JP, Solnon A, Tassin A, Graindorge L, Gras D. Non-physiological increase of AV conduction time in sinus disease patients programmed in AAIR-based pacing mode. J Interv Card Electrophysiol. 2012;35:219-26.

Baufreton C, Chrétien JM, Moreau-Cordier F, Moreau F, Portefaix H, Branchereau H, Huez JF, Richard I, Saint-André JP. [Assessment of scientific production after initial medical education at the Faculty of Medicine of Angers from 2002 to 2008]. Presse Med. 2012;41:e213-9. doi: 10.1016/j.lpm.2011.11.026. Epub 2012 Feb 13. French.

Gourraud JB, Kyndt F, Fouchard S, Rendu E, Jaafar P, Gully C, Gacem K, Dupuis JM, Longueville A, Baron E, Karakachoff M, Cebron JP, Chatel S, Schott JJ, Le Marec H, Probst V. Identification of a strong genetic background for progressive cardiac conduction defect by epidemiological approach. Heart. 2012;98:1305-10.

Leenhardt A, Defaye P, Mouton E, Delay M, Delarche N, Dupuis JM, Bizeau O, Mabo P, Cheggour S, Babuty D; OPERA Registry Investigators. First inappropriate implantable cardioverter defibrillator therapy is often due to inaccurate device programming: analysis of the French OPERA registry. Europace. 2012;14:1465-74.

Davy JM, Hoffmann E, Frey A, Jocham K, Rossi S, Dupuis JM, Frabetti L, Ducloux P, Prades E, Jauvert G. Near elimination of ventricular pacing in SafeR mode compared to DDD modes: a randomized study of 422 patients. Pacing Clin Electrophysiol. 2012;35:392-402. Erratum in: Pacing Clin Electrophysiol. 2012;35:909.

Sanchez O, Trinquart L, Planquette B, Couturaud F, Verschuren F, Caille V, Meneveau N, Pacouret G, Roy PM, Righini M, Perrier A, Bertoletti L, Parent F, Lorut C, Meyer G. Echocardiography and PESI have independent prognostic role in pulmonary embolism. Eur Respir J. 2012 Dec 20. [Epub ahead of print]

de Decker L, de Boisjolly-Bonnefoi JM, Roy PM, Berrut G, Potel G, Annweiler C, Beauchet O. Comorbidities and treatment-limiting decisions in older adults dying in the emergency department: is there an association? J Am Geriatr Soc. 2012;60:1370-2.

Penaloza A, Roy PM, Kline J. Risk stratification and treatment strategy of pulmonary embolism. Curr Opin Crit Care. 2012;18:318-25.

Penaloza A, Roy PM, Kline J, Verschuren F, LE Gal G, Quentin-Georget S, Delvau N, Thys F. Performance of age-adjusted D-dimer cut-off to rule out pulmonary embolism. J Thromb Haemost. 2012;10:1291-6.

Babaud J, Ridereau-Zins C, Bouhours G, Lebigot J, Le Gall R, Bertrais S, Roy PM, Aubé C. Benefit of the Vittel criteria to determine the need for whole body scanning in a severe trauma patient. Diagn Interv Imaging. 2012;93:371-9.

Kline JA, Roy PM, Than MP, Hernandez J, Courtney DM, Jones AE, Penaloza A, Pollack CV Jr. Derivation and validation of a multivariate model to predict mortality from pulmonary embolism with cancer: The POMPE-C tool. Thromb Res. 2012;129:e194-9.

Penaloza A, Verschuren F, Dambrine S, Zech F, Thys F, Roy PM. Performance of the Pulmonary Embolism Rule-out Criteria (the PERC rule) combined with low clinical probability in high prevalence population. Thromb Res. 2012;129:e189-93.

Foucault A, Hilpert L, Hédoire F, Saloux E, Gomes S, Pellissier A, Scanu P, Champ-Rigot L, Milliez P. Apical aneurism and myocardial bridging in a patient with hypertrophic cardiomyopathy: association or consequence of the myocardial bridging? Cardiol J. 2012;19(6):643-5.

Foucault A, Amelot M, Gomes S, Champ-Rigot L, Saloux E, Pellissier A, Labombarda F, Scanu P, Milliez P. Primary prevention with a defibrillator: are therapies always really optimized before implantation? Europace. 2012 Nov;14(11):1572-7.

Benouda L, Roule V, Foucault A, Dahdouh Z, Lebon A, Milliez P. Conduction disturbances in Tako Tsubo cardiomyopathy: a cause or a consequence? Int J Cardiol. 2012 Aug 9;159(1):61-2.

Alexandre J, Foucault A, Coutance G, Scanu P, Milliez P. Digitalis intoxication induced by an acute accidental poisoning by lily of the valley. Circulation. 2012 Feb 28;125(8):1053-5.

Alexandre J, Foucault A, Scanu P. Cryoablation of two accessory pathways in a single session: appraisal of a direct cryoablation approach in right septal locations. Arch Cardiovasc Dis. 2011 Nov;104(11):593-5

Amelot M, Foucault A, Scanu P, Gomes S, Champ-Rigot L, Pellissier A, Milliez P. Comparison of outcomes in patients with abandoned versus extracted implantable cardioverter defibrillator leads. Arch Cardiovasc Dis. 2011 Nov;104(11):572-7.

 

2011:

Tamareille S, Mateus V, Ghaboura N, Jeanneteau J, Croué A, Henrion D, Furber A, Prunier F. RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning. Basic Res Cardiol. 2011 Nov;106(6):1329-39.

Lefthériotis G, Abraham P, Le Corre Y, Le Saux O, Henrion D, Ducluzeau PH, Prunier F, Martin L. Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum. J Vasc Surg. 2011 Nov;54(5):1390-4.

Ghaboura N, Tamareille S, Ducluzeau PH, Grimaud L, Loufrani L, Croué A, Tourmen Y, Henrion D, Furber A, Prunier F. Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling. Basic Res Cardiol. 2011 Jan;106(1):147-62.

Righini M, Roy PM, Meyer G, Verschuren F, Aujesky D, Le Gal G. The Simplified Pulmonary Embolism Severity Index (PESI): validation of a clinical prognostic model for pulmonary embolism. J Thromb Haemost. 2011 Oct;9(10):2115-7.

Aujesky D, Roy PM, Verschuren F, Righini M, Osterwalder J, Egloff M, Renaud B, Verhamme P, Stone RA, Legall C, Sanchez O, Pugh NA, N'gako A, Cornuz J, Hugli O, Beer HJ, Perrier A, Fine MJ, Yealy DM. Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet. 2011 Jul 2;378(9785):41-8.

Bertoletti L, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Bounameaux H, Perrier A, Righini M. Prognostic value of the Geneva prediction rule in patients in whom pulmonary embolism is ruled out. J Intern Med. 2011 Apr;269(4):433-40.

Hugli O, Righini M, Le Gal G, Roy PM, Sanchez O, Verschuren F, Meyer G, Bounameaux H, Aujesky D. The pulmonary embolism rule-out criteria (PERC) rule does not safely exclude pulmonary embolism. J Thromb Haemost. 2011 Feb;9(2):300-4.

Pinaud F, Loufrani L, Toutain B, Lambert D, Vandekerckhove L, Henrion D, Baufreton C. In vitro protection of vascular function from oxidative stress and inflammation by pulsatility in resistance arteries. J Thorac Cardiovasc Surg. 2011 Nov;142(5):1254-62.

Baufreton C, Pinaud F, Corbeau JJ, Chevailler A, Jolivot D, Ter Minassian A, Henrion D, de Brux JL. Increased cerebral blood flow velocities assessed by transcranial Doppler examination is associated with complement activation after cardiopulmonary bypass. Perfusion. 2011 Mar;26(2):91-8.

Ramadan A, Lagarce F, Tessier-Marteau A, Thomas O, Legras P, Macchi L, Saulnier P, Benoit JP. Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study. Int J Nanomedicine. 2011;6:2941-51. doi: 10.2147/IJN.S25791. Epub 2011 Nov 21.

Ramond A, Bouton C, Richard I, Roquelaure Y, Baufreton C, Legrand E, Huez JF. Psychosocial risk factors for chronic low back pain in primary care--a systematic review. Fam Pract. 2011 Feb;28(1):12-21. doi: 10.1093/fampra/cmq072. Epub 2010 Sep 10. Review.

Perruche F, Elie C, d'Ussel M, Ray P, Thys F, Bleichner G, Roy PM, Schmidt J, Gayet A, Pateron D, Le Joubioux E, Porcher N, Gamand P, Claessens YE. Anxiety and depression are unrecognised in emergency patients admitted to the observation care unit. Emerg Med J. 2011 Aug;28(8):662-5. doi: 10.1136/emj.2009.089961. Epub 2010 Aug 3.

Meyer G, Roy PM, Gilberg S, Perrier A. [Pulmonary embolism]. Praxis (Bern 1994). 2011 Feb 16;100(4):237-9. doi: 10.1024/1661-8157/a000444. Review. German.

 

2010:

Treguer F, Donal E, Tamareille S, Ghaboura N, Derumeaux G, Furber A, Prunier F. Speckle tracking imaging improves in vivo assessment of EPO-induced myocardial salvage early after ischemia-reperfusion in rats. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1679-86.

Danchin N, Fauchier L, Marijon E, Barnay C, Furber A, Mabo P, Bernard P, Blanc JJ, Jouven X, Le Heuzey JY, Charbonnier B, Ferrières J, Simon T; French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) Investigators. Impact of early statin therapy on development of atrial fibrillation at the acute stage of myocardial infarction: data from the FAST-MI register. Heart. 2010 Nov;96(22):1809-14.

Meyer G, Roy PM, Gilberg S, Perrier A. Pulmonary embolism. BMJ. 2010 Apr 13;340:c1421.

Douma RA, le Gal G, Söhne M, Righini M, Kamphuisen PW, Perrier A, Kruip MJ, Bounameaux H, Büller HR, Roy PM. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ. 2010 Mar 30;340:c1475.

Sanchez O, Trinquart L, Caille V, Couturaud F, Pacouret G, Meneveau N, Verschuren F, Roy PM, Parent F, Righini M, Perrier A, Lorut C, Tardy B, Benoit MO, Chatellier G, Meyer G. Prognostic factors for pulmonary embolism: the prep study, a prospective multicenter cohort study. Am J Respir Crit Care Med. 2010 Jan 15;181(2):168-73.

Thuillier R, Favreau F, Celhay O, Macchi L, Milin S, Hauet T. Thrombin inhibition during kidney ischemia-reperfusion reduces chronic graft inflammation and tubular atrophy. Transplantation. 2010 Sep 27;90(6):612-21.

Tessier-Marteau A, Croquefer S, Meziani F, Cau S, Asfar P, Macchi L. Acquired factor V inhibitor in a context of sepsis and disseminated intravascular coagulation. Am J Hematol. 2010 Feb;85(2):145-6. doi: 10.1002/ajh.21594.

Baufreton C. Role of surgical factors in strokes after cardiac surgery. Arch Cardiovasc Dis. 2010 May;103(5):326-32. doi: 10.1016/j.acvd.2009.12.007. Epub 2010 Apr 24. Review.

Tessier-Marteau A, Geneviève F, Godon A, Macchi L, Zandecki M. [Automated hematology analysers and spurious counts. Part 1. Platelets].  Ann Biol Clin (Paris). 2010 Jul-Aug;68(4):393-407. doi: 10.1684/abc.2010.0451. French.

Hezard N, Tessier-Marteau A, Macchi L. New insight in antiplatelet therapy monitoring in cardiovascular patients: from aspirin to thienopyridine. Cardiovasc Hematol Disord Drug Targets. 2010 Sep 1;10(3):224-33. Review.

 

2009:

Tamareille S, Ghaboura N, Treguer F, Khachman D, Croué A, Henrion D, Furber A, Prunier F. Myocardial reperfusion injury management: erythropoietin compared with postconditioning. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2035-43.

Prunier F, Pottier P, Clairand R, Mercier A, Hajjar RJ, Planchon B, Furber A. Chronic erythropoietin treatment decreases post-infarct myocardial damage in rats without venous thrombogenic effect. Cardiology. 2009;112(2):129-34.

Roy PM, Durieux P, Gillaizeau F, Legall C, Armand-Perroux A, Martino L, Hachelaf M, Dubart AE, Schmidt J, Cristiano M, Chretien JM, Perrier A, Meyer G. A computerized handheld decision-support system to improve pulmonary embolism diagnosis: a randomized trial. Ann Intern Med. 2009 Nov 17;151(10):677-86.

Roy PM. Diagnosis of venous thromboembolism. BMJ. 2009 Aug 19;339:b2799.

Righini M, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Kossovsky M, Bressollette L, Meyer G, Perrier A, Bounameaux H. Complete venous ultrasound in outpatients with suspected pulmonary embolism. J Thromb Haemost. 2009 Mar;7(3):406-12.

2008:

Prunier F, Kawase Y, Gianni D, Scapin C, Danik SB, Ellinor PT, Hajjar RJ, Del Monte F. Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation. 2008 Aug 5;118(6):614-24. Epub 2008 Jul 21. PubMed PMID: 18645052.

Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif JC, Tanguay JF, Hajjar RJ. Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J Am Coll Cardiol. 2008 Mar 18;51(11):1112-9.

Prunier F, Brette S, Delépine S, Geslin P, Le Jeune JJ, Furber AP. Three-dimensional MRI assessment of regional wall stress after acute myocardial infarction predicts postdischarge cardiac events. J Magn Reson Imaging. 2008 Mar;27(3):516-21.

Donzé J, Le Gal G, Fine MJ, Roy PM, Sanchez O, Verschuren F, Cornuz J, Meyer G, Perrier A, Righini M, Aujesky D. Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism. Thromb Haemost. 2008 Nov;100(5):943-8.

Righini M, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Rutschmann O, Nonent M, Cornuz J, Thys F, Le Manach CP, Revel MP, Poletti PA, Meyer G, Mottier D, Perneger T, Bounameaux H, Perrier A. Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial. Lancet. 2008 Apr 19;371(9621):1343-52.

Belin de Chantemèle EJ, Retailleau K, Pinaud F, Vessières E, Bocquet A, Guihot AL, Lemaire B, Domenga V, Baufreton C, Loufrani L, Joutel A, Henrion D. Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2216-24.

Dumont O, Pinaud F, Guihot AL, Baufreton C, Loufrani L, Henrion D. Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine. Cardiovasc Res. 2008 Feb 1;77(3):600-8.

Savoir-faire

Prestations de services

- Etudes hémodynamiques cardiaque chez le petit animal (rat, souris)

- Echocardiographie du petit animal (rat, souris)

- Etudes en cœur isolé perfusé de type Langendorff (rat, souris)

- Infarctus du myocarde par ischémie-reperfusion (rat, souris)

- Centre de lecture des IRM cardiaques (Détection automatique des contours) : Protocoles de régression de l'hypertrophie ventriculaire gauche chez l'hypertendu, essais thérapeutiques dans le Remodelage Post-infarctus

- Imagerie de l’infarctus du myocarde chez l'homme (échocardiographie, IRM)

- Analyse des flux coronaires par IRM et doppler intra-coronaire

Equipements principaux et/ou particuliers

- Modèle de cœur isolé perfusé (Langendorff) (rat, souris)

- Isolement de cardiomyocytes (rat, souris)

- Modèle d’infarctus du myocarde chez le rat et la souris

- Hémodynamique cardiaque du petit animal

- 3 setups « modèles chirurgicaux du petit animal»

- Télémétrie ECG implantable

- Echocardiographie (rat, souris)

- Western blot

Partenariats

Partenariats institutionnels

- UMR CNRS 6214, INSERM U771, Angers (D Henrion)

- UMR INSERM 1063, Angers (R Andriantsitohaina, C Martinez)

- INSERM U744 - Institut Pasteur de Lille (F Pinet)

- INSERM U955, Créteil (A Berdeaux, B Ghaleh)

- UMR INSERM 1060, Lyon (M Ovize)

- INSERM U1042, Grenoble (D Godin-Ribuot)

- UMR INSERM U1050 - CNRS 7241 (S Germain)

- Services de cardiologie des CHU de Brest (M Gilard), Tours (D Angoulvant), Montpellier (C Piot), Lyon (M Ovize), Toulouse (M Elbaz), Nantes (P Guerin)

- Equipes de recherche clinique sur la thrombose veineuse : Genève (A Perrier), Lausanne (D Aujesky), Bruxelles (F Verschuren), Saint-Etienne (H Decousus), Brest (G Le Gal, D Mottier), Paris HEGP (G Meyer)...

Partenariats industriels

Participation à de nombreux essais cliniques à promotion industrielle dans le domaine de la coronaropathie, l'insuffisance cardiaque, la rythmologie, la maladie veineuse thrombo-embolique.

Contacts

Adresse postale

Cardioprotection, Remodelage et Thrombose (CRT)
Université d'Angers
UFR Sciences Médicales
Rue Haute de Reculée
49045 ANGERS CEDEX 01

Responsable(s)

fabrice.prunier @ univ-angers.fr

Contacts

Fabrice PRUNIER | Directeur
Tel : 02 41 35 51 47 | fabrice.prunier @ univ-angers.fr

Nouveau Laboratoire